通过动力学拆分获得光学纯的大位阻（杂）芳基烷基醇。
Optically pure bulky (hetero)arylalkyl carbinols via kinetic resolution.
机构信息
Shanghai Key Laboratory of Functional Materials Chemistry, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.
出版信息
Chem Commun (Camb). 2011 Oct 14;47(38):10632-4. doi: 10.1039/c1cc14591f. Epub 2011 Sep 5.
PMID:21892500
Abstract
Planar chiral nucleophilic catalyst Fc-PIP was employed in the kinetic resolution of bulky (hetero)arylalkyl carbinols delivering unreacted alcohols with extremely high enantiomeric excess (>99.0% ees) in ideal conversions ranging from 50.4-56.7%.
摘要
手性亲核催化剂 Fc-PIP 被用于动力学拆分大位阻（杂）芳基烷基醇，未反应的醇以理想的转化率 (>99.0%ee) 获得极高的对映过量 (>99.0%ee)。
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