Department of Critical Care Medicine, Jinhua Central Hospital, 351# Mingyue Road, Jinhua, 321000, Zhejiang, People's Republic of China.
J Anesth. 2011 Dec;25(6):904-16. doi: 10.1007/s00540-011-1217-1. Epub 2011 Sep 4.
Stroke volume variation (SVV) appears to be a good predictor of fluid responsiveness in critically ill patients. However, a wide range of its predictive values has been reported in recent years. We therefore undertook a systematic review and meta-analysis of clinical trials that investigated the diagnostic value of SVV in predicting fluid responsiveness.
Clinical investigations were identified from several sources, including MEDLINE, EMBASE, WANFANG, and CENTRAL. Original articles investigating the diagnostic value of SVV in predicting fluid responsiveness were considered to be eligible. Participants included critically ill patients in the intensive care unit (ICU) or operating room (OR) who require hemodynamic monitoring.
A total of 568 patients from 23 studies were included in our final analysis. Baseline SVV was correlated to fluid responsiveness with a pooled correlation coefficient of 0.718. Across all settings, we found a diagnostic odds ratio of 18.4 for SVV to predict fluid responsiveness at a sensitivity of 0.81 and specificity of 0.80. The SVV was of diagnostic value for fluid responsiveness in OR or ICU patients monitored with the PiCCO or the FloTrac/Vigileo system, and in patients ventilated with tidal volume greater than 8 ml/kg.
SVV is of diagnostic value in predicting fluid responsiveness in various settings.
每搏量变异度（SVV）似乎是预测危重病患者液体反应性的一个很好的指标。然而，近年来其预测值的范围很广。因此，我们对研究 SVV 预测液体反应性的诊断价值的临床试验进行了系统回顾和荟萃分析。
从多个来源（包括 MEDLINE、EMBASE、WANFANG 和 CENTRAL）中确定了临床研究。符合条件的研究是调查 SVV 预测液体反应性的诊断价值的原始文章。研究对象包括需要血流动力学监测的重症监护病房（ICU）或手术室（OR）中的危重病患者。
共有来自 23 项研究的 568 名患者纳入我们的最终分析。基础 SVV 与液体反应性相关， pooled correlation coefficient 为 0.718。在所有情况下，我们发现 SVV 预测液体反应性的诊断优势比为 18.4，其敏感性为 0.81，特异性为 0.80。SVV 在接受 PiCCO 或 FloTrac/Vigileo 系统监测的 OR 或 ICU 患者中，以及在潮气量大于 8ml/kg 的患者中，对液体反应性有诊断价值。
SVV 在预测各种情况下的液体反应性方面具有诊断价值。
