艾滋病疫苗的合理设计进展。
Progress in the rational design of an AIDS vaccine.
机构信息
Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 40 Convent Drive, MSC 3005, Bethesda, MD 20892, USA.
出版信息
Philos Trans R Soc Lond B Biol Sci. 2011 Oct 12;366(1579):2759-65. doi: 10.1098/rstb.2011.0096.
Abstract
Human immunodeficiency virus-1 (HIV-1) has a high degree of genetic and antigenic diversity that has impeded the development of an effective vaccine using traditional methods. We are attempting to develop an AIDS vaccine by employing strategies that include structural biology and computational modelling, in an effort to develop immunogens capable of eliciting neutralizing antibodies of the requisite breadth and potency against circulating strains of HIV-1.
摘要
人类免疫缺陷病毒 1 型（HIV-1）具有高度的遗传和抗原多样性，这阻碍了使用传统方法开发有效的疫苗。我们正在尝试通过采用结构生物学和计算建模等策略来开发艾滋病疫苗，以开发能够诱导针对 HIV-1 循环株的必要广度和效力的中和抗体的免疫原。
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