Institute of Molecular and Cellular Anatomy, RWTH Aachen University, 52057 Aachen, Germany.
J Cell Biol. 2011 Sep 5;194(5):669-78. doi: 10.1083/jcb.201008095.
Epithelia are exposed to multiple forms of stress. Keratin intermediate filaments are abundant in epithelia and form cytoskeletal networks that contribute to cell type-specific functions, such as adhesion, migration, and metabolism. A perpetual keratin filament turnover cycle supports these functions. This multistep process keeps the cytoskeleton in motion, facilitating rapid and protein biosynthesis-independent network remodeling while maintaining an intact network. The current challenge is to unravel the molecular mechanisms underlying the regulation of the keratin cycle in relation to actin and microtubule networks and in the context of epithelial tissue function.
上皮细胞会受到多种形式的压力。角蛋白中间丝在上皮细胞中含量丰富，形成细胞骨架网络，有助于细胞类型特有的功能，如黏附、迁移和代谢。一个持续的角蛋白丝周转循环支持这些功能。这个多步骤的过程使细胞骨架保持运动，在不依赖于蛋白质生物合成的情况下促进快速的网络重塑，同时保持网络的完整。目前的挑战是揭示角蛋白周期在与肌动蛋白和微管网络相关的调节以及在上皮组织功能方面的分子机制。
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