Magee K L, Hsu S M, Tucker S B
Department of Dermatology, University of Texas Medical School, Houston 77030.
Arch Dermatol. 1990 Jun;126(6):760-2.
Eleven patients with alopecia areata, ranging from patchy disease to alopecia universalis, were treated with intralesional interferon alfa-2 on a selected area of alopecia. Follow-up at 3 months revealed local terminal hair growth in one patient. At 12 months, variable disease activity was seen. Regional lymphadenopathy, a new finding with interferon, was seen in four patients during the treatment. Immunohistochemical studies showed some changes in the inflammatory infiltrates and in HLA-DR expression that may be related to the interferon or to the dynamics of the inflammatory infiltrate in alopecia areata. Interferon, at the dosage and treatment schedule used in our trial, had no significant effect on alopecia areata.
11名斑秃患者，病情从斑片状到全秃不等，在选定的脱发区域接受了病灶内注射α-2干扰素治疗。3个月的随访显示，1名患者局部有终毛生长。12个月时，可见疾病活动情况不一。4名患者在治疗期间出现了区域淋巴结病，这是使用干扰素后出现的新情况。免疫组织化学研究显示，炎症浸润和HLA-DR表达有一些变化，这可能与干扰素或斑秃中炎症浸润的动态变化有关。在我们的试验中使用的剂量和治疗方案下，干扰素对斑秃没有显著疗效。
