Department of Dermatology, Riyadh Military Hospital, Riyadh, Saudi Arabia.
Dermatol Ther. 2011 May-Jun;24(3):355-63. doi: 10.1111/j.1529-8019.2011.01419.x.
Alopecia areata is a common form of nonscarring alopecia. It affects males and females equally and has no racial predilection. It usually affects the scalp, but any hair-bearing area can be involved. It presents as patchy hair loss, loss of hair on the entire scalp (alopecia totalis), or the whole body (alopecia universalis). The histopathology varies according to the disease stage, but usually a perifollicular lymphocytic infiltrate is seen. The course of the disease and response to treatment are unpredictable. Various therapeutic modalities are used including topical, intralesional, and systemic agents, although none are curative or preventive. This article will review the available topical and intralesional agents that are used in the treatment of alopecia areata and suggest a management approach based on the age of the patient and extent of the disease.
斑秃是一种常见的非瘢痕性脱发。它可发生于男女，无种族倾向。通常累及头皮，但也可发生于身体其他有毛发的部位。表现为斑片状脱发，整个头皮脱发（全秃）或全身毛发脱落（普秃）。组织病理学改变随疾病阶段而异，但通常可见毛囊周围淋巴细胞浸润。疾病的病程和对治疗的反应是不可预测的。目前使用了多种治疗方法，包括局部、皮损内和系统药物治疗，但均不能治愈或预防疾病。本文将综述斑秃的局部和皮损内治疗药物，并根据患者的年龄和疾病的严重程度提出治疗建议。
