Kayano H, Katayama I
Department of Pathology, Saitama Medical School, Japan.
Arch Pathol Lab Med. 1990 Jun;114(6):580-4.
A case of primary hepatic lymphoma presenting as intravascular lymphomatosis was diagnosed in a 69-year-old woman who presented with symptoms related to the digestive tract. These symptoms were followed by neurologic disorders, including disturbance of sensation and mentality, and pathologic reflexes suggestive of a broad intracerebral lesion. Computed tomography of the brain showed an ill-defined, low-density area in the bilateral parietotemporal lobes. Autopsy revealed a well-circumscribed hepatic tumor, 6 cm in diameter, and scattered hemorrhagic foci in the cerebral cortexes. Microscopically, the hepatic tumor was a diffuse lymphoma, large cell, of the B-cell type. The small vessels of the brain were found to be packed with lymphoma cells, having caused the florid neurologic manifestations.
一名69岁女性被诊断为表现为血管内淋巴瘤病的原发性肝淋巴瘤，该患者最初出现与消化道相关的症状，随后出现神经系统疾病，包括感觉和精神障碍以及提示广泛脑内病变的病理反射。脑部计算机断层扫描显示双侧顶颞叶有边界不清的低密度区。尸检发现肝脏有一个边界清晰的肿瘤，直径6厘米，大脑皮质有散在的出血灶。显微镜下，肝脏肿瘤为弥漫性B细胞大细胞淋巴瘤。发现脑内小血管充满淋巴瘤细胞，导致了明显的神经系统表现。
