Departments of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita, Osaka, Japan.
Gynecol Obstet Invest. 2011;72(3):196-202. doi: 10.1159/000323962. Epub 2011 Sep 1.
BACKGROUND/AIMS: An intraoperative diagnosis in cases with primary and metastatic ovarian carcinomas is important for adequate treatment. The aim of the present study was to find a reliable method to discriminate primary from metastatic mucinous adenocarcinomas (MACs) of the ovary intraoperatively.
Clinical features of all primary and metastatic mucinous ovarian carcinomas diagnosed from 1994 to 2008 at the Osaka University and Osaka Rosai Hospitals, Osaka, Japan, were reviewed retrospectively.
Among the 73 MACs, 51 (70%) and 22 cases (30%) were diagnosed as primary and metastatic ovarian carcinomas, respectively. The distributions of tumor size, patient age, and serum CA125 level were significantly different between primary and metastatic cases. Our algorithm that categorizes patients ≥50 years whose tumor size was <10 cm into metastatic cases, and patients <50 years, or the ones whose tumor size was ≥10 cm, into primary tumors, provided an 84% accuracy in our population.
A more reliable method to discriminate primary from metastatic MACs of the ovary by patient age and serum tumor markers was derived from our study population.
背景/目的：在原发性和转移性卵巢癌病例中进行术中诊断对于充分治疗非常重要。本研究的目的是寻找一种可靠的方法，以便在术中区分原发性和转移性卵巢黏液性腺癌（MAC）。
回顾性分析了 1994 年至 2008 年期间在日本大阪大学和大阪 Rosai 医院诊断的所有原发性和转移性卵巢黏液性腺癌的临床特征。
在 73 例 MAC 中，51 例（70%）和 22 例（30%）分别诊断为原发性和转移性卵巢癌。原发性和转移性病例的肿瘤大小、患者年龄和血清 CA125 水平分布差异显著。我们的算法将年龄≥50 岁且肿瘤大小<10cm 的患者归类为转移性病例，而将年龄<50 岁或肿瘤大小≥10cm 的患者归类为原发性肿瘤，在我们的人群中具有 84%的准确率。
本研究人群得出了一种通过患者年龄和血清肿瘤标志物区分原发性和转移性卵巢 MAC 的更可靠方法。
