神经阻滞剂恶性综合征（NMS）：由止吐药引起的罕见表现——病例报告。

Neuroleptic Malignant syndrome (NMS): a rare presentation induced by an antiemetic - case report.

机构信息

South Essex Partnership University Foundation Trust, Calnwood Court, Luton, Bedfordshire, UK.

出版信息

Psychiatr Danub. 2011 Sep;23 Suppl 1:S43-5.

Abstract

Neuroleptic Malignant Syndrome is one of the life threatening complications of antipsychotic psychotropic medication. We here report a case of a 39 years old male who has had a diagnosis of paranoid schizophrenia since the age of 18. He had been on antipsychotic therapy since then. He was stable on a combination of antipsychotics. He had mild hyper-salivation for a long time but was not very concerned about it. He requested and was prescribed Hyoscine Hydrobromide 300 mcg BD for hyper-salivation. There was no other medication change. After 5 days of starting Kwells, the patient presented with Neuroleptic Malignant syndrome. One has to watch for NMS while starting Hyoscine Hydrbromide for someone on antispychotics.

摘要

神经阻滞剂恶性综合征是抗精神病类药物的一种危及生命的并发症。我们在此报告一例 39 岁男性患者，他自 18 岁起被诊断为偏执型精神分裂症。从那时起，他就一直在接受抗精神病药物治疗。他的病情一直稳定，服用了多种抗精神病药物联合治疗。他有很长时间的轻度唾液分泌过多，但不是很在意。他要求并开了氢溴酸东莨菪碱 300 微克，每日两次，用于治疗唾液分泌过多。没有其他药物变化。开始服用 Kwells 后 5 天，患者出现神经阻滞剂恶性综合征。对于正在服用抗精神病药物的患者，在开始使用氢溴酸东莨菪碱时，必须注意是否出现 NMS。