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颅内动脉瘤的治疗。血流导向(Silk)支架重建母动脉。

Treatment of intracranial aneurysms. Reconstruction of the parent artery with flow-diverting (Silk) stent.

机构信息

Department of Neuroradiology, University Hospital Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark.

出版信息

Neuroradiology. 2012 Jul;54(7):709-18. doi: 10.1007/s00234-011-0949-9. Epub 2011 Sep 6.

Abstract

INTRODUCTION

Since the flow diverters (FDs) have been introduced it is possible to treat aneurysms that are considered difficult or impossible to treat with usual endovascular or surgical methods. It is still uncertain which aneurysms are suitable for this new treatment. We present the periprocedural complications, immediate result, late complications, imaging follow-up at 6 and 12 months and clinical follow-up at 2-23 months.

METHODS

Twenty-two patients with 26 wide-necked or blister-like aneurysms had 23 treatments with implantation of a Silk stent. Eleven patients had re-canalizations, and 11 patients were either untreated or had been treated for another aneurysm.

RESULTS

Periprocedural complications were seen in four treatments (17%). However, none of these had clinical consequences. Mortality and morbidity rates were 1 of 22 (5%) and 1 of 22 (5%), respectively. Clinical outcome was unchanged in 16 patients (72%), 3 patients improved (14%) and 3 patients worsened (14%). The end-of-procedure angiography did not show complete occlusion of any of the aneurysms, but at 6 months follow-up angiography, 17 of 25 aneurysms (68%) were completely occluded, and at 12 months, 18 of 21 aneurysms (86%) were occluded.

CONCLUSION

The effect of the Silk FD in terms of occlusion of the aneurysms seems to occur mainly during the first 6 months after placement but continues during the following time. Most delayed complications occur immediately after discontinuing the anticoagulation medication. Considering the complexity of the aneurysms treated, the rate of complications is acceptable.

摘要

介绍

自从血流导向装置(FD)问世以来,对于那些用常规的血管内或手术方法被认为难以或不可能治疗的动脉瘤,可以进行治疗了。目前还不确定哪些动脉瘤适合这种新的治疗方法。我们报告了围手术期并发症、即刻结果、迟发性并发症、6 个月和 12 个月的影像学随访以及 2-23 个月的临床随访结果。

方法

22 名患者的 26 个宽颈或泡状动脉瘤接受了 23 次 Silk 支架植入治疗。11 名患者发生再通,11 名患者未治疗或治疗了另一个动脉瘤。

结果

4 次治疗(17%)出现围手术期并发症,但均无临床后果。死亡率和发病率分别为 1/22(5%)和 1/22(5%)。16 名患者(72%)的临床结局保持不变,3 名患者(14%)改善,3 名患者(14%)恶化。手术结束时的血管造影未显示任何动脉瘤完全闭塞,但在 6 个月的血管造影随访中,25 个动脉瘤中的 17 个(68%)完全闭塞,在 12 个月时,21 个动脉瘤中的 18 个(86%)闭塞。

结论

Silk FD 在闭塞动脉瘤方面的效果似乎主要发生在放置后的前 6 个月内,但在随后的时间内仍在继续。大多数迟发性并发症发生在停止抗凝药物治疗后立即。考虑到治疗的动脉瘤的复杂性,并发症的发生率是可以接受的。

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