Young R C, Bookman M A, Longo D L
Fox Chase Cancer Center, Philadelphia, PA 19111.
J Natl Cancer Inst Monogr. 1990(10):55-60.
In the past several decades, Hodgkin's disease has been transformed from a uniformly fatal illness to one that can be treated with the expectation of long-term remission or cure in the majority of patients. Because patients now survive for long periods after curative intervention, various complications have been identified. The spectrum of complications following curative therapy is quite diverse and includes immunologic, cardiovascular, pulmonary, thyroid, and gonadal dysfunction. In addition, second malignant neoplasms in the form of acute leukemia as well as secondary solid tumors have now been documented to occur with increased frequency in patients cured of Hodgkin's disease.
在过去几十年里，霍奇金淋巴瘤已从一种普遍致命的疾病转变为一种多数患者有望通过治疗实现长期缓解或治愈的疾病。由于患者在接受根治性干预后现在能存活很长时间，已发现了各种并发症。根治性治疗后的并发症范围相当广泛，包括免疫、心血管、肺部、甲状腺和性腺功能障碍。此外，现已证明，霍奇金淋巴瘤治愈患者中，急性白血病形式的第二原发性恶性肿瘤以及继发性实体瘤的发生频率有所增加。
