School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, People's Republic of China.
J Nat Prod. 2011 Sep 23;74(9):1881-7. doi: 10.1021/np200319x. Epub 2011 Sep 6.
Eight new pseudoguaianolides (1-8), two new guaianolides (9 and 10), and 14 known sesquiterpenes were isolated from the aerial parts of Inula hupehensis. The structures were elucidated using spectroscopic methods and circular dichroism analysis. All compounds were tested for inhibitory activities against LPS-induced nitric oxide production in RAW264.7 macrophages. Compounds 13 and 22 were found to inhibit nitric oxide production potently, with IC50 values of 0.9 and 0.6 μM, respectively. Preliminary structure-activity relationships for these compounds are proposed.
从旋覆花的地上部分分离得到了 8 个新的伪愈创木烷内酯（1-8）、2 个新的愈创木烷内酯（9 和 10）和 14 个已知的倍半萜。通过光谱方法和圆二色性分析阐明了这些结构。所有化合物均测试了对 LPS 诱导的 RAW264.7 巨噬细胞中一氧化氮产生的抑制活性。发现化合物 13 和 22 具有很强的抑制一氧化氮产生的活性，IC50 值分别为 0.9 和 0.6 μM。提出了这些化合物的初步结构-活性关系。
