温郁金中的愈创木烷型倍半萜及其对一氧化氮生成的抑制作用。
Guaiane-type sesquiterpenes from Curcuma wenyujin and their inhibitory effects on nitric oxide production.
作者信息
Lou Yan, Zhao Feng, He Hao, Peng Kai-Feng, Zhou Xiao-Hua, Chen Li-Xia, Qiu Feng
机构信息
Department of Natural Products Chemistry, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China.
出版信息
J Asian Nat Prod Res. 2009 Aug;11(8):737-47. doi: 10.1080/10286020903042358.
Four new guaiane-type sesquiterpenes (1S,4S,5S,10R)-zedoarondiol, zedoalactones D, E, and F (1-4), along with 10 known ones (5-14), were isolated from Curcuma wenyujin Y.H. Chen et C. Ling. The structures of these new compounds were elucidated by spectroscopic methods. The inhibitory effects of compounds 1-14 on nitric oxide production in lipopolysaccharide-activated macrophages were evaluated.
从温郁金（Curcuma wenyujin Y.H. Chen et C. Ling）中分离得到4个新的愈创木烷型倍半萜（1S,4S,5S,10R）-莪术二醇、莪术内酯D、E和F（1-4），以及10个已知化合物（5-14）。通过光谱方法阐明了这些新化合物的结构。评估了化合物1-14对脂多糖激活的巨噬细胞中一氧化氮产生的抑制作用。
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