State Key Laboratory for Chirosciences, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong.
Org Lett. 2011 Oct 7;13(19):5370-3. doi: 10.1021/ol2022577. Epub 2011 Sep 6.
A rhodium-catalyzed one-pot three-component coupling reaction was developed for the synthesis of quaternary α,α-heterodiaryl carboxylic esters. This reaction involves cross-coupling of the arylrhodium(I) complexes with α-aryldiazoacetates to form oxa-π-allylrhodium complexes. With KOtBu and alkyl halides, tandem alkylation of the allyl complex occurs to form a quaternary stereocenter at the carbenic carbon.
发展了一种铑催化的一锅法三组分偶联反应，用于合成季铵盐α,α-杂芳基羧酸酯。该反应涉及芳基铑（I）配合物与α-芳基重氮乙酸酯的交叉偶联，形成氧杂-π-烯丙基铑配合物。用 KOtBu 和卤代烷烃，烯丙基配合物发生串联烷基化反应，在碳正离子上形成季碳立体中心。
