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铑（II）催化芳烃与重氮化合物反应直接合成5-芳基巴比妥酸

Direct Synthesis of 5-Aryl Barbituric Acids by Rhodium(II)-Catalyzed Reactions of Arenes with Diazo Compounds.

作者信息

Best Daniel, Burns David J, Lam Hon Wai

机构信息

School of Chemistry, University of Nottingham, University Park, Nottingham, NG7 2RD (UK).

出版信息

Angew Chem Int Ed Engl. 2015 Jun 15;54(25):7410-3. doi: 10.1002/anie.201502324. Epub 2015 May 8.

DOI:10.1002/anie.201502324
PMID:25959544
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4479025/
Abstract

A commercially available rhodium(II) complex catalyzes the direct arylation of 5-diazobarbituric acids with arenes, allowing straightforward access to 5-aryl barbituric acids. Free N-H groups are tolerated on the barbituric acid, with no complications arising from N-H insertion processes. This method was applied to the concise synthesis of a potent matrix metalloproteinase (MMP) inhibitor.

摘要

一种市售的铑（II）配合物催化5-重氮巴比妥酸与芳烃的直接芳基化反应，可直接制得5-芳基巴比妥酸。巴比妥酸上的游离N-H基团可耐受，不会因N-H插入过程而产生并发症。该方法应用于一种强效基质金属蛋白酶（MMP）抑制剂的简洁合成。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/44dc/4479025/f3b41569927d/anie0054-7410-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/44dc/4479025/e2a3191c6055/anie0054-7410-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/44dc/4479025/c75682acdcb4/anie0054-7410-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/44dc/4479025/d56b4fdfb4a0/anie0054-7410-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/44dc/4479025/f3b41569927d/anie0054-7410-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/44dc/4479025/e2a3191c6055/anie0054-7410-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/44dc/4479025/c75682acdcb4/anie0054-7410-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/44dc/4479025/d56b4fdfb4a0/anie0054-7410-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/44dc/4479025/f3b41569927d/anie0054-7410-f7.jpg

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