School of Electrical and Computer Engineering, Oklahoma State University, Stillwater, OK, USA.
Technol Cancer Res Treat. 2011 Oct;10(5):403-16. doi: 10.7785/tcrt.2012.500218.
This work investigates, by means of analytical and simulation studies, the performance of spectrally-constrained image reconstruction in Continuous-Wave or Direct-Current (DC) and Frequency Domain (FD) near-infrared optical tomography. A recent analytic approach for estimating the accuracy of target recovery and the level of background artifact for optical tomography at single wavelength, based on the analysis of parametric reconstruction uncertainty level (PRUL), is extended to spectrally-constrained optical tomography. The analytical model is implemented to rank three sets of wavelengths that had been used as spectral prior in an independent experimental study. Subsequent simulation appraises the recovery of oxygenated hemoglobin (HbO), deoxygenated hemoglobin (Hb), water (H2O), scattering amplitude (A), and scattering power (b) using DC-only, DC-excluded FD, and DC-included FD, based on the three sets of wavelengths as the spectral prior. The simulation results support the analytic ranking of the performance of the three sets of spectral priors, and generally agree with the performance outcome of DC-only versus that of DC-excluded FD and DC-included FD. Specifically, this study indicate that: 1) the rank of overall quality of chromophore recovery is Hb, H2O, and HbO from the highest to lowest; and in the scattering part the A is always better recovered than b. This outcome does suggest that the DC-only information gives rise to unique solution to the image reconstruction routine under the given spectral prior. 2) DC-information is not-redundant in FD-reconstruction, as the artifact levels of DC-included FD reconstruction are always lower than those of DC-excluded FD. 3) The artifact level as represented by the noise-to-contrast-ratio is almost always the lowest in DC-only, leading to generally better resolution of multiple targets of identical contrasts over the background than in FD. However, the FD could outperform DC in the recovery of scattering properties including both A and b when the spectral prior is less optimal, implying the benefit of phase-information in scattering recovery in the context of spectrally-constrained optical tomography.
这项工作通过分析和模拟研究,研究了连续波或直流 (DC) 和频域 (FD) 近红外光层析成像中谱约束图像重建的性能。最近提出了一种基于参数化重建不确定性水平 (PRUL) 分析的单波长光层析成像中目标恢复准确性和背景伪影水平的估计方法,该方法扩展到谱约束光层析成像中。分析模型用于对在独立实验研究中用作光谱先验的三组波长进行排序。随后的模拟使用直流仅、直流排除 FD 和直流包含 FD 基于三组波长作为光谱先验,评估了含氧血红蛋白 (HbO)、去氧血红蛋白 (Hb)、水 (H2O)、散射幅度 (A) 和散射功率 (b) 的恢复情况。模拟结果支持三种光谱先验性能的分析排名,并且通常与直流仅与直流排除 FD 和直流包含 FD 的性能结果一致。具体而言,这项研究表明:1) 发色团恢复整体质量的排名从最高到最低依次为 Hb、H2O 和 HbO;在散射部分,A 的恢复总是优于 b。这一结果表明,在给定的光谱先验下,直流信息仅为图像重建常规提供了独特的解决方案。2) 在 FD 重建中,直流信息不是冗余的,因为直流包含 FD 重建的伪影水平总是低于直流排除 FD 重建的伪影水平。3) 以噪声与对比度比表示的伪影水平在直流仅时几乎总是最低的,导致在 FD 中背景下多个相同对比度的目标的分辨率通常更好。然而,当光谱先验不太理想时,FD 可以在散射特性的恢复中优于直流,包括 A 和 b,这意味着在谱约束光层析成像中相位信息在散射恢复中的益处。