连续波多光谱漫射光学层析成像中的唯一性与波长优化

Uniqueness and wavelength optimization in continuous-wave multispectral diffuse optical tomography.

作者信息

Corlu Alper, Durduran Turgut, Choe Regine, Schweiger Martin, Hillman Elizabeth M C, Arridge Simon R, Yodh Arjun G

机构信息

Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

出版信息

Opt Lett. 2003 Dec 1;28(23):2339-41. doi: 10.1364/ol.28.002339.

DOI:10.1364/ol.28.002339

PMID:14680175

Abstract

We derive conditions for the unique and simultaneous recovery of chromophore concentrations and scattering coefficients in multispectral continuous-wave diffuse optical tomography. These conditions depend strongly on measurement wavelengths. We introduce and demonstrate a general methodology for choosing those wavelengths, which yields superior separation of scattering from absorption and superior separation of one chromophore from another. Application of these concepts should significantly improve the fidelity of continuous-wave diffuse near-infrared optical tomography in tissues.

摘要

我们推导了在多光谱连续波扩散光学层析成像中唯一且同时恢复发色团浓度和散射系数的条件。这些条件强烈依赖于测量波长。我们引入并演示了一种选择这些波长的通用方法，该方法能实现散射与吸收的更好分离以及一种发色团与另一种发色团的更好分离。这些概念的应用应能显著提高组织中连续波扩散近红外光学层析成像的保真度。