National Cheng-Kung University, Department of Photonics, Tainan 701, Taiwan.
J Biomed Opt. 2011 Aug;16(8):087007. doi: 10.1117/1.3609821.
In our previous studies, we have shown that the diffusing probe geometry can be used in conjunction with a two-layer diffusion model to accurately recover the absorption and scattering properties of skin in vivo. By modifying the original design to the diffusing probe with planar source (DPPS) geometry, we have also demonstrated that the efficiency of the accompanying multilayer diffusion model is comparable to that of a standard semi-infinite diffusion model; thus, precise quantification of superficial tissue optical properties in real time using a diffusion model becomes possible. In this study, the performance of the DPPS diffusion model is evaluated using Monte Carlo simulations and phantom measurements. It is found that the DPPS geometry is advantageous over the conventional planar source illumination geometry in interrogating superficial volumes of samples. In addition, our simulation results have shown that the DPPS geometry is capable of accurately recovering the optical properties of 50-μm thick epidermis and could be very useful in detecting cutaneous melanoma that has a radius as small as 250 μm.
在之前的研究中，我们已经表明，扩散探针几何形状可以与两层扩散模型结合使用，以准确恢复体内皮肤的吸收和散射特性。通过将原始的扩散探针平面源（DPPS）几何形状进行修改，我们还证明了伴随的多层扩散模型的效率与标准半无限扩散模型相当；因此，使用扩散模型实时精确量化表面组织光学特性成为可能。在这项研究中，使用蒙特卡罗模拟和体模测量评估 DPPS 扩散模型的性能。结果表明，DPPS 几何形状在探测样品的浅层体积方面优于传统的平面源照明几何形状。此外，我们的模拟结果表明，DPPS 几何形状能够准确地恢复 50μm 厚表皮的光学特性，对于检测半径小至 250μm 的皮肤黑色素瘤非常有用。
