Department of Photonics, National Cheng-Kung University, Tainan 701, Taiwan.
Opt Lett. 2010 Nov 15;35(22):3739-41. doi: 10.1364/OL.35.003739.
Previously, we reported using a diffusing probe in conjunction with a two-layer diffusion model for accurately recovering the optical properties of superficial volumes. However, the two-layer diffusion equation is computationally less efficient than a standard diffusion equation (SDE) by 3 orders of magnitude. In this Letter, we present a new approach extended from the diffusing probe geometry that enables the use of a diffusion model that has efficiency comparable to an SDE. Our Monte Carlo simulation results indicate that this new approach is not only very accurate but also sensitive to the presence of 0.5 mm(3) inhomogeneities and could be used for monitoring the early progression of skin melanoma.
此前，我们曾报道过使用扩散探针与双层扩散模型相结合，以准确恢复浅层体积的光学特性。然而，双层扩散方程在计算效率上比标准扩散方程（SDE）低 3 个数量级。在本研究中，我们提出了一种从扩散探针几何形状扩展而来的新方法，该方法可使用与 SDE 效率相当的扩散模型。我们的蒙特卡罗模拟结果表明，这种新方法不仅非常准确，而且对 0.5mm3 不均匀性的存在也很敏感，可用于监测皮肤黑色素瘤的早期进展。
