Department of Family Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
Clin Endocrinol (Oxf). 2012 Jul;77(1):47-50. doi: 10.1111/j.1365-2265.2011.04217.x.
Chemerin, a recently discovered adipocytokine, may be linked to obesity and obesity-associated metabolic complications. However, the relationship between visceral fat accumulation and chemerin is still unknown. Therefore, we investigated the relationship between serum chemerin levels and body composition as measured by computed tomography (CT).
We recruited 173 men and women without histories of diabetes or cardiovascular disease.
Biomarkers of metabolic risk factors and body composition by computed tomography were assessed. Serum chemerin levels were measured by enzyme-linked immunosorbent assay.
Chemerin levels correlated with body mass index (BMI), waist circumference, abdominal visceral fat area, blood pressure, fasting insulin, homoeostasis model of assessment-insulin resistance, total cholesterol, triglyceride, creatinine, aspartate aminotransferase and alanine aminotransferase. By stepwise multiple regression analysis, abdominal visceral fat area, blood pressure and total cholesterol levels independently affected chemerin levels.
Abdominal visceral fat accumulation, blood pressure and lipid profile were significantly associated with serum chemerin levels. Our findings suggest that chemerin may be a mediator that links visceral obesity to cardiovascular risk factors.
趋化素是一种新发现的脂肪细胞因子，可能与肥胖及其相关的代谢并发症有关。然而，内脏脂肪堆积与趋化素之间的关系尚不清楚。因此，我们通过计算机断层扫描（CT）研究了血清趋化素水平与身体成分之间的关系。
我们招募了 173 名无糖尿病或心血管疾病病史的男性和女性。
通过 CT 评估代谢危险因素和身体成分的生物标志物。通过酶联免疫吸附试验测量血清趋化素水平。
趋化素水平与体重指数（BMI）、腰围、腹部内脏脂肪面积、血压、空腹胰岛素、胰岛素抵抗评估的稳态模型、总胆固醇、甘油三酯、肌酐、天门冬氨酸氨基转移酶和丙氨酸氨基转移酶相关。通过逐步多元回归分析，腹部内脏脂肪面积、血压和总胆固醇水平独立影响趋化素水平。
腹部内脏脂肪堆积、血压和血脂谱与血清趋化素水平显著相关。我们的研究结果表明，趋化素可能是一种将内脏肥胖与心血管危险因素联系起来的介质。
