Department of Paediatrics, Charles University in Prague, Faculty of Medicine in Pilsen, Faculty Hospital, Pilsen, Czech Republic.
Helicobacter. 2011 Sep;16 Suppl 1:59-64. doi: 10.1111/j.1523-5378.2011.00882.x.
This article reviewed the important publications on Helicobacter pylori research with children between April 2010 and March 2011. The most interesting studies in the last year lend further weight to the evidence for vertical transmission of H. pylori. The discovery of a potential role for jhp0562, the gene which encodes for the cell envelope protein glycosyltransferase, in the progression to peptic ulcer disease is also very interesting as it may provide a novel way to distinguish children at risk of peptic ulcer disease from those who are not, and so determine those who requires treatment to eradicate H. pylori. The rise in non-H. pylori-associated ulcers and erosions continues to be reported with no apparent risk factors for these ulcers identified to date. High levels of treatment failure continue to be reported, and there remains an urgent need for more effective treatment regimes for children.
本文回顾了 2010 年 4 月至 2011 年 3 月期间发表的有关儿童幽门螺杆菌研究的重要文献。去年最有趣的研究进一步证实了幽门螺杆菌的垂直传播。发现 jhp0562 基因（编码细胞包膜蛋白糖基转移酶）在发展为消化性溃疡疾病方面的潜在作用也非常有趣，因为它可能为区分有消化性溃疡疾病风险的儿童和没有风险的儿童提供一种新方法，从而确定需要治疗来根除幽门螺杆菌的儿童。目前尚未发现这些溃疡的明显危险因素，但与非幽门螺杆菌相关的溃疡和糜烂仍在持续报道。治疗失败的比例仍然很高，因此迫切需要为儿童制定更有效的治疗方案。
