University Children's Hospital, Ljubljana, Slovenia.
Helicobacter. 2012 Sep;17 Suppl 1:43-8. doi: 10.1111/j.1523-5378.2012.00982.x.
This review summarizes important pediatric studies published from April 2011 up to March 2012. Proteomics profile of ulcerogenic Helicobacter pylori strains was defined in the most interesting study of the last year. The antigen stool test is becoming the "gold standard" in prevalence studies, and according to the last epidemiologic studies, the prevalence of H. pylori infection in childhood is not decreasing any more in the developed world. The resistance rate of H. pylori strains is high in children. Therefore, among other important issues concerning H. pylori in pediatrics, guidelines published by ESPGHAN and NASPGHAN last year also recommended culture and susceptibility testing before first-line treatment in areas with high or unknown antibiotic resistance rates.
这篇综述总结了 2011 年 4 月至 2012 年 3 月期间发表的重要儿科研究。在去年最有趣的研究中，定义了溃疡相关幽门螺杆菌菌株的蛋白质组学特征。抗原粪便检测正在成为流行研究中的“金标准”，根据最新的流行病学研究，在发达国家，儿童幽门螺杆菌感染的流行率不再下降。儿童幽门螺杆菌菌株的耐药率很高。因此，除了儿科幽门螺杆菌的其他重要问题外，ESPUGHAN 和 NASPGHAN 去年发布的指南还建议在高耐药率或未知耐药率地区，在一线治疗前进行培养和药敏试验。
