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重症监护中的毒理学:第 1 部分:一般概述和治疗方法。

Toxicology in the ICU: Part 1: general overview and approach to treatment.

机构信息

Department of Medical Toxicology, Banner Good Samaritan Medical Center, Phoenix, AZ.

Department of Medical Toxicology, Banner Good Samaritan Medical Center, Phoenix, AZ.

出版信息

Chest. 2011 Sep;140(3):795-806. doi: 10.1378/chest.10-2548.

DOI:10.1378/chest.10-2548
PMID:21896525
Abstract

Poisonings, adverse drug effects, and envenomations continue to be commonly encountered. Patients often present critically ill and warrant ICU admission. Many other patients who are initially stable have the potential for rapid deterioration and require continuous cardiopulmonary and neurologic monitoring. Given the potential for rapid deterioration, and because patients need continuous monitoring, ICU admission is frequently required. This article is the first of a three-part series to be published in CHEST; it discusses general management, laboratory tests, enhanced elimination, and emerging therapies. The second article will address the management of specific overdoses; the last will cover plants, mushrooms, envenomations, and heavy metals.

摘要

中毒、药物不良反应和毒液中毒仍然是常见的。患者常出现病危,需要 ICU 入院治疗。许多最初病情稳定的其他患者有迅速恶化的可能,需要持续进行心肺和神经监测。鉴于可能迅速恶化,且患者需要持续监测,因此经常需要 ICU 入院治疗。本文是 CHEST 杂志上发表的三部分系列文章的第一篇;它讨论了一般管理、实验室检查、增强清除和新出现的治疗方法。第二篇文章将讨论特定药物过量的处理;最后一篇将涵盖植物、蘑菇、毒液和重金属。

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Toxicology in the ICU: Part 1: general overview and approach to treatment.重症监护中的毒理学:第 1 部分:一般概述和治疗方法。
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2
Toxicology in the ICU: part 3: natural toxins.重症监护中的毒理学:第 3 部分:天然毒素。
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Healthcare (Basel). 2025 Feb 21;13(5):474. doi: 10.3390/healthcare13050474.
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Diphenhydramine Overdose: A Case Report and Topic Review of Prehospital Diagnosis and Treatment.苯海拉明过量:一例病例报告及院前诊断与治疗的专题综述
Cureus. 2024 Oct 2;16(10):e70719. doi: 10.7759/cureus.70719. eCollection 2024 Oct.
3
Diphenhydramine overdose detected early by integration of toxidrome and electrocardiography and treated with venoarterial extracorporeal membrane oxygenation: a case report.
早期通过中毒症状群和心电图整合检测到苯海拉明过量,并通过静脉动脉体外膜肺氧合治疗:一例报告。
J Int Med Res. 2023 Oct;51(10):3000605231205449. doi: 10.1177/03000605231205449.
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[Acute intoxications: markers for screening, diagnosis and therapy monitoring].[急性中毒:筛查、诊断及治疗监测的标志物]
Med Klin Intensivmed Notfmed. 2019 May;114(4):302-312. doi: 10.1007/s00063-019-0566-7. Epub 2019 Apr 3.
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Donepezil: an unusual therapy for acute diphenhydramine overdose.多奈哌齐:一种治疗急性苯海拉明过量中毒的非常规疗法。
BMJ Case Rep. 2019 Mar 20;12(3):e226836. doi: 10.1136/bcr-2018-226836.
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