Department of Neuropsychiatry,Seoul National University Bundang Hospital, Seongnam, Gyeonggido, Korea.
Invest Ophthalmol Vis Sci. 2011 Oct 10;52(11):7954-8. doi: 10.1167/iovs.11-8050.
A population-based cross-sectional study to investigate the association between depression and dry eye disease (DED) in a community-dwelling elderly population.
The subjects were 657 Korean elders ≥ 65 years of age randomly selected from an official household registration database in Yongin, Korea. DED symptoms were assessed using the six-item Dry Eye Questionnaire. DED signs were evaluated using the Schirmer test, fluorescein stain score, tear film break-up time (BUT). Depression was assessed using the Korean version of the Short Geriatric Depression Scale (SGDS-K). The association between DED and depression was evaluated using logistic linear analyses.
The SGDS-K score correlated with the number of positive responses in the Dry Eye Questionnaire (r = 0.229, P < 0.001), but not with tear film break-up time (r = 0.041, P = 0.139) or Schirmer test score (r = 0.048, P = 0.642). In the binary logistic regression model, female sex (P = 0.014), residence in urban areas (P < 0.001), depression (P < 0.001), and Schirmer score of ≤ 5 mm (P = 0.035) were associated with the risk of DED. Depression was associated with the risk of DED (P < 0.001) in the patients with Schirmer score > 5 mm but not in those with Schirmer score ≤ 5 mm (P = 0.290).
Depression was associated with DED symptoms in subjects with normal or mildly reduced tear production.
本研究采用基于人群的横断面研究，旨在调查社区居住的老年人群中抑郁与干眼疾病（DED）之间的关联。
本研究的研究对象为韩国龙仁市从官方户籍数据库中随机抽取的 657 名≥65 岁的韩国老年人。使用六条目干眼问卷评估 DED 症状。使用 Schirmer 测试、荧光素染色评分和泪膜破裂时间（BUT）评估 DED 体征。使用韩国版简易老年抑郁量表（SGDS-K）评估抑郁。使用逻辑线性分析评估 DED 和抑郁之间的关联。
SGDS-K 评分与干眼问卷的阳性回答数呈正相关（r = 0.229，P < 0.001），但与泪膜破裂时间（r = 0.041，P = 0.139）或 Schirmer 测试评分（r = 0.048，P = 0.642）无关。在二元逻辑回归模型中，女性（P = 0.014）、居住在城市地区（P < 0.001）、抑郁（P < 0.001）和 Schirmer 评分≤5mm（P = 0.035）与 DED 风险相关。在 Schirmer 评分>5mm 的患者中，抑郁与 DED 风险相关（P < 0.001），而在 Schirmer 评分≤5mm 的患者中则无此相关性（P = 0.290）。
在泪液产生正常或轻度减少的受试者中，抑郁与 DED 症状相关。
