Department of Preventive Medicine, Kangwon National University Hospital, Kangwon National University School of Medicine, Chuncheon, Korea.
Department of Ophthalmology, Kangwon National University Hospital, Kangwon National University School of Medicine, Chuncheon, Korea.
Eye (Lond). 2024 Apr;38(5):917-922. doi: 10.1038/s41433-023-02803-6. Epub 2023 Oct 28.
To evaluate the association between dry eye disease (DED) and various psychiatric and systemic diseases in an adult Korean population aged 40 years or older.
Population-based cross-sectional data of 6,732 participants aged ≥40 years was extracted from the Korea National Health and Nutrition Examination Survey 2017-2018 (KNHANES VII). Data including DED, demographic variables, behavioral factors, psychiatric conditions, and systemic diseases was analysed to determine the prevalence and psychiatric and systemic risk factors for DED.
The weighted prevalence of DED was 7.9 ± 0.4% (mean ± SE). Multivariate analysis showed that female sex and urban residence were associated with an increased risk of DED. The prevalence of DED was lower in patients aged ≥70 years than in those aged 40-69 years. Self-reported psychological conditions including perceived stress and depression were associated with the risk of DED. Self-reported Systemic conditions, such as rheumatoid arthritis, degenerative arthritis, osteoporosis, ischemic heart disease, and chronic renal failure had association with an increased risk of DED.
DED may be associated with several self-reported psychiatric and systemic conditions, which highlights the need for an integrated approach to manage these diseases for optimal treatment of DED.
评估在韩国≥40 岁成年人中，干眼疾病（DED）与各种精神和系统性疾病之间的关联。
从 2017-2018 年韩国国家健康和营养检查调查（KNHANES VII）中提取了 6732 名≥40 岁参与者的基于人群的横断面数据。分析包括 DED、人口统计学变量、行为因素、精神状况和系统性疾病的数据，以确定 DED 的患病率和精神及系统性危险因素。
DED 的加权患病率为 7.9±0.4%（平均值±SE）。多变量分析显示，女性和城市居住与 DED 风险增加有关。≥70 岁患者的 DED 患病率低于 40-69 岁患者。自我报告的心理状况，包括感知压力和抑郁，与 DED 的风险有关。自我报告的系统性疾病，如类风湿关节炎、退行性关节炎、骨质疏松症、缺血性心脏病和慢性肾衰竭，与 DED 风险增加有关。
DED 可能与几种自我报告的精神和系统性疾病有关，这强调了需要采取综合方法来管理这些疾病，以实现 DED 的最佳治疗。
