Kazami Sayaka, Usui Takeo, Osada Hiroyuki
Chemical Library Validation Team, Chemical Biology Core Facility, RIKEN Advanced Science Institute, Saitama.
Biosci Biotechnol Biochem. 2011;75(9):1853-5. doi: 10.1271/bbb.110334. Epub 2011 Sep 7.
F-actin-stabilizing drugs induce actin aggresome formation. In this study, we found that an actin-depolymerizing drug, latrunculin A (LatA), induced actin aggresomes. Actin stress fibers were retracted and disappeared in minutes, but a large aggresome formed in consequence of LatA treatment. Because cytochalasin D and mycalolide also induced aggresome formation, these results suggest that actin aggresome formation is a common cellular response to actin toxins.
F-肌动蛋白稳定药物可诱导肌动蛋白聚集体形成。在本研究中，我们发现一种肌动蛋白解聚药物，即拉春库林A（LatA），可诱导肌动蛋白聚集体形成。肌动蛋白应力纤维在数分钟内回缩并消失，但LatA处理后会形成一个大的聚集体。由于细胞松弛素D和肉珊瑚素也能诱导聚集体形成，这些结果表明肌动蛋白聚集体形成是细胞对肌动蛋白毒素的一种常见反应。
