高血压大鼠脑内血管紧张素II 1型受体的差异表达
Differential brain angiotensin-II type I receptor expression in hypertensive rats.
作者信息
Braga Valdir A
机构信息
Veterinary Sciences Department, Center for Agrarian Sciences, Federal University of Paraíba, Areia, PB 58397-000, Brazil.
出版信息
J Vet Sci. 2011 Sep;12(3):291-3. doi: 10.4142/jvs.2011.12.3.291.
Abstract
Blood-borne angiotensin-II (Ang-II) has profound effects in the brain. We tested the hypothesis that Ang-II-dependent hypertension involves differential Ang-II type I (AT(1)) receptors expression in the subfornical organ (SFO) and the rostral ventrolateral medulla (RVLM). Male Wistar rats were implanted with 14-day osmotic minipump filled with Ang-II (150 ng/kg/min) or saline. AT(1) receptor mRNA levels were detected in the SFO and RVLM by reverse transcription-polymerase chain reaction (RT-PCR). Ang-II caused hypertension (134 ± 10 mmHg vs. 98 ± 9 mmHg, n = 9, p < 0.05). RT-PCR revealed that Ang-II infusion induced increased AT(1) receptor mRNA levels in RVLM and decreased in SFO. Our data suggest that Ang-II-induced hypertension involves differential expression of brain AT(1) receptors.
摘要
血源性血管紧张素II（Ang-II）对大脑有深远影响。我们验证了以下假说：依赖Ang-II的高血压涉及穹窿下器（SFO）和延髓头端腹外侧区（RVLM）中血管紧张素II 1型（AT(1)）受体的差异表达。给雄性Wistar大鼠植入填充有Ang-II（150 ng/kg/分钟）或生理盐水的14天渗透微型泵。通过逆转录-聚合酶链反应（RT-PCR）检测SFO和RVLM中AT(1)受体mRNA水平。Ang-II导致高血压（134±10 mmHg对98±9 mmHg，n = 9，p<0.05）。RT-PCR显示，输注Ang-II可诱导RVLM中AT(1)受体mRNA水平升高，而SFO中则降低。我们的数据表明，Ang-II诱导的高血压涉及脑AT(1)受体的差异表达。
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