血管紧张素 II 衍生的活性氧在延髓心血管反射处理中起关键作用。
Angiotensin II-derived reactive oxygen species underpinning the processing of the cardiovascular reflexes in the medulla oblongata.
机构信息
Laboratory of Pharmaceutical Technology, Federal University of Paraíba, João Pessoa, PB, Brazil.
出版信息
Neurosci Bull. 2011 Aug;27(4):269-74. doi: 10.1007/s12264-011-1529-z.
Abstract
The brainstem is a major site in the central nervous system involved in the processing of the cardiovascular reflexes such as the baroreflex and the peripheral chemoreflex. The nucleus tractus solitarius and the rostral ventrolateral medulla are 2 important brainstem nuclei, and they play pivotal roles in autonomic cardiovascular regulation. Angiotensin II is one of the neurotransmitters involved in the processing of the cardiovascular reflexes within the brainstem. It is well-known that one of the mechanisms by which angiotensin II exerts its effect is via the activation of pathways that generate reactive oxygen species (ROS). In the central nervous system, ROS are reported to be involved in several pathological diseases such as hypertension, heart failure and sleep apnea. However, little is known about the role of ROS in the processing of the cardiovascular reflexes within the brainstem. The present review mainly discussed some recent findings documenting a role for ROS in the processing of the baroreflex and the peripheral chemoreflex in the brainstem.
摘要
脑干是中枢神经系统的主要部位，参与处理心血管反射，如压力反射和外周化学反射。孤束核和延髓头端腹外侧区是两个重要的脑干核团，它们在自主心血管调节中起着关键作用。血管紧张素 II 是参与脑干内心血管反射处理的神经递质之一。众所周知，血管紧张素 II 发挥作用的机制之一是通过激活产生活性氧（ROS）的途径。在中枢神经系统中，ROS 被报道参与了几种病理疾病，如高血压、心力衰竭和睡眠呼吸暂停。然而，关于 ROS 在脑干内心血管反射处理中的作用知之甚少。本文主要讨论了一些最近的发现，这些发现记录了 ROS 在处理脑干中的压力反射和外周化学反射中的作用。
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