Institute of Endocrinology and Nutrition, Medicine School and Unit of Investigation, Hospital Rio Hortega, University of Valladolid, Valladolid, Spain.
J Endocrinol Invest. 2012 Jul;35(7):625-8. doi: 10.3275/7908. Epub 2011 Sep 6.
Some studies have pointed to a role of uncoupling protein 3 (UCP3) in the regulation of fat distribution. The aim of our study was to investigate the influence of -55CT polymorphism of UCP3 gene on fat mass and adipocytokines in naïve patients with Type 2 diabetes mellitus.
A population of 57 patients with Type 2 diabetes mellitus and obesity was analyzed in a cross-sectional study. Genotype of UCP3 gene -55CT was studied.
Forty-six patients (80.7%) had the 55CC genotype and 11 patients (19.3%) the 55CT genotype. Fat mass (39.1±15.4 vs 53.3±16.8 kg; p<0.05), weight (92.6±17.7 vs 106.3±17.3 kg; p<0.05), body mass index (36.2±6.5 vs 42.8±5.2 kg/m²; p<0.05), waist circumference (112.8±13.6 vs 127.9±12.3 cm; p<0.05), waist-to-hip ratio (0.96±0.1 vs 1.1±0.2; p<0.05), C reactive protein (6.1±5.1 vs 12.4±6.1 mg/dl; p<0.05) and leptin (92.8±86 vs 114±89 ng/ml; p<0.05) were higher in patients with mutant genotype than in those with wild genotype.
C reactive protein and fat mass were higher in the mutant group of -55 CT UCP3 gene diabetic patients than in wild type patients.
一些研究表明解偶联蛋白 3（UCP3）在脂肪分布调节中起作用。本研究的目的是探讨 UCP3 基因-55CT 多态性对初诊 2 型糖尿病肥胖患者体脂和脂肪细胞因子的影响。
本研究采用横断面研究分析了 57 例 2 型糖尿病肥胖患者。研究了 UCP3 基因-55CT 多态性的基因型。
46 例（80.7%）患者为 55CC 基因型，11 例（19.3%）患者为 55CT 基因型。脂肪质量（39.1±15.4 比 53.3±16.8kg;p<0.05）、体重（92.6±17.7 比 106.3±17.3kg;p<0.05）、体重指数（36.2±6.5 比 42.8±5.2kg/m²;p<0.05）、腰围（112.8±13.6 比 127.9±12.3cm;p<0.05）、腰臀比（0.96±0.1 比 1.1±0.2;p<0.05）、C 反应蛋白（6.1±5.1 比 12.4±6.1mg/dl;p<0.05）和瘦素（92.8±86 比 114±89ng/ml;p<0.05）在突变基因型患者中均高于野生型患者。
与野生型患者相比，UCP3 基因-55CT 突变型糖尿病患者的 C 反应蛋白和脂肪质量较高。
