益生菌与免疫健康。
Probiotics and immune health.
机构信息
Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
出版信息
Curr Opin Gastroenterol. 2011 Oct;27(6):496-501. doi: 10.1097/MOG.0b013e32834baa4d.
Abstract
PURPOSE OF REVIEW
The beneficial effects of probiotics have been demonstrated in many diseases. One of the major mechanisms of probiotic action is through the regulation of host immune response. This review highlights the recent scientific research findings that advance our understanding of probiotic regulation of the host immune response with potential application for disease prevention and treatment.
RECENT FINDINGS
Probiotic genomic and proteomic studies have identified several genes and specific compounds derived from probiotics, which mediate immunoregulatory effects. Studies regarding the biological consequences of probiotics in host immunity suggested that they regulate the functions of systemic and mucosal immune cells and intestinal epithelial cells. Thus, probiotics showed therapeutic potential for diseases, including several immune response-related diseases, such as allergy, eczema, viral infection, and potentiating vaccination responses.
SUMMARY
Probiotics may provide novel approaches for both disease prevention and treatment. However, the results of clinical studies regarding probiotic application are preliminary and require further confirmation.
摘要
目的综述
益生菌在许多疾病中都表现出有益的作用。益生菌作用的主要机制之一是通过调节宿主的免疫反应。本综述强调了最近的科学研究发现，这些发现增进了我们对益生菌调节宿主免疫反应的理解，这可能对疾病的预防和治疗具有应用潜力。
最近的发现
益生菌的基因组和蛋白质组研究已经确定了几个基因和特定的化合物来源于益生菌，这些基因和化合物介导免疫调节作用。关于益生菌在宿主免疫中的生物学后果的研究表明，它们调节全身和黏膜免疫细胞以及肠上皮细胞的功能。因此，益生菌在包括过敏、湿疹、病毒感染和增强疫苗反应等几种与免疫反应相关的疾病的治疗方面显示出了潜力。
总结
益生菌可能为疾病的预防和治疗提供新的方法。然而，关于益生菌应用的临床研究结果尚初步，需要进一步证实。
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