从南海来源的链霉菌 SCSIO 01127 中分离得到的新螺缩环四肽抗生素 lobophorin E 和 F。
Lobophorins E and F, new spirotetronate antibiotics from a South China Sea-derived Streptomyces sp. SCSIO 01127.
机构信息
CAS Key Laboratory of Marine Bio-resources Sustainable Utilization, RNAM Center for Marine Microbiology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, PR China.
出版信息
J Antibiot (Tokyo). 2011 Nov;64(11):711-6. doi: 10.1038/ja.2011.78. Epub 2011 Sep 7.
The strain SCSIO 01127, isolated from the South China Sea sediment, was identified as a member of Streptomyces by the 16S rDNA sequence analysis. Two new spirotetronate antibiotics lobophorins E (1) and F (2), along with two known analogs lobophorins A (3) and B (4), were isolated from Streptomyces sp. SCSIO 01127. Their structures were elucidated on the basis of detailed IR, NMR and MS spectroscopic analyses. The new compound lobophorin F (2) showed antibacterial activities against Staphylococcus aureus ATCC 29213 and Enterococcus faecalis ATCC 29212 with MIC values of 8 μg ml(-1) for both the strains, better than that of lobophorin B (4). Lobophorin F (2) also displayed better cytotoxic activities than lobophorin B (4), with IC(50) of 6.82, 2.93 and 3.16 μM against SF-268, MCF-7 and NCI-H460, respectively.
从南海沉积物中分离得到的菌株 SCSIO 01127 通过 16S rDNA 序列分析被鉴定为链霉菌属的一个成员。从链霉菌属 SCSIO 01127 中分离得到了两种新的螺环四烯抗生素洛泊菌素 E（1）和 F（2），以及两种已知的类似物洛泊菌素 A（3）和 B（4）。基于详细的 IR、NMR 和 MS 光谱分析确定了它们的结构。新化合物洛泊菌素 F（2）对金黄色葡萄球菌 ATCC 29213 和粪肠球菌 ATCC 29212 表现出抗菌活性，MIC 值均为 8μg/ml(-1)，优于洛泊菌素 B（4）。洛泊菌素 F（2）对 SF-268、MCF-7 和 NCI-H460 的细胞毒性活性也优于洛泊菌素 B（4），IC(50)分别为 6.82、2.93 和 3.16μM。
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