阿普唑仑与丙咪嗪治疗抑郁症的双盲对照评估
A double-blind evaluation of alprazolam and imipramine in the treatment of major depression.
机构信息
Department of Psychiatry, National Institute of Mental Health and Neuro Sciences, Bangalore 560029.
出版信息
Indian J Psychiatry. 1991 Apr;33(2):104-7.
Abstract
This report describes the results of a multicentre collaborative study comparing the safety and efficacy of alprazolam with imipramine in patients suffering from major depressive disorder. Two hundred and eight patients diagnosed as major depression as per DSM-III criteria were randomly allocated to alprazolam (N= 105) or imipramine (N = 103) in a double-blind fashion. Detailed assessments were carried out for a period of six weeks. Results revealed that alprazolam was as effective as imipramine as an antidepressant. Side effects were less frequently reported with alprazolam.
摘要
本报告描述了一项多中心合作研究的结果，该研究比较了阿普唑仑和丙咪嗪在患有重度抑郁症患者中的安全性和疗效。根据 DSM-III 标准诊断为重度抑郁症的 208 例患者被随机分配至阿普唑仑（N=105）或丙咪嗪（N=103）组，采用双盲法。详细评估持续 6 周。结果表明，阿普唑仑作为抗抑郁药与丙咪嗪同样有效。阿普唑仑的副作用报告较少。
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