Bigoniya Papiya, Shukla A, Singh C S, Gotiya P
Department of Pharmacology, Radharaman College of Pharmacy, Radharaman Group of Institutions, Ratibad, Bhopal, Madhya Pradesh, India.
J Pharmacol Pharmacother. 2011 Jul;2(3):179-84. doi: 10.4103/0976-500X.83283.
To compare the anti-ulcer activity of buffered pantoprazole tablet against plain pantoprazole in pyloric ligated rats.
In vivo pyloric ligated ulcerogenesis model was used to assess the effect of buffered pantoprazole on the volume of the gastric content, pH, total and free acidity, and ulcerogenic lesion. Pantoprazole level in gastric content and concurrently in stomach tissue was assessed by High Performance Liquid Chromatography (HPLC) analysis.
Buffered tablet effectively increases the pH of the gastric content above 4 up to 6 h (P<0.001) protecting pantoprazole from acid degradation resulting in high concentration in the gastric content and stomach tissue.
This study substantiates better, faster and prolonged bioavailability of pantoprazole-buffered tablet compared to plain pantoprazole.
比较缓释泮托拉唑片与普通泮托拉唑片对幽门结扎大鼠的抗溃疡活性。
采用体内幽门结扎溃疡形成模型，评估缓释泮托拉唑对胃内容物体积、pH值、总酸度和游离酸度以及溃疡病变的影响。通过高效液相色谱（HPLC）分析评估胃内容物及同时胃组织中的泮托拉唑水平。
缓释片能有效提高胃内容物pH值至4以上并维持6小时（P<0.001），保护泮托拉唑不被酸降解，从而使胃内容物和胃组织中浓度较高。
本研究证实，与普通泮托拉唑相比，泮托拉唑缓释片具有更好、更快和更长时间的生物利用度。
