Department of Family Medicine, University Hospitals Case Medical Center, Cleveland, OH 4410, USA.
J Clin Sleep Med. 2011 Aug 15;7(4):397-8. doi: 10.5664/JCSM.1200.
Cardiac arrhythmias have been reported in up to half of individuals with obstructive sleep apnea (OSA) and have been proposed to be one of the factors contributing to their increased mortality. Several studies have demonstrated evidence of an association between OSA and a number of cardiac arrhythmias. The mechanisms of arrhythmogenesis in OSA may be due to enhanced vagal output triggered by a combination of apnea and hypoxemia. This case demonstrates a dose-dependent reduction in atrial ectopy with increasing continuous positive airway pressure (CPAP) in the setting of mild sleep apnea.
多达一半的阻塞性睡眠呼吸暂停（OSA）患者会出现心律失常，并被认为是导致其死亡率增加的因素之一。多项研究表明，OSA 与多种心律失常之间存在关联。OSA 中心律失常的发生机制可能是由于呼吸暂停和低氧血症的组合触发增强的迷走神经输出。本病例表明，在轻度睡眠呼吸暂停的情况下，随着持续气道正压通气（CPAP）的增加，房性早搏呈剂量依赖性减少。
