Luz Gabriela Pontes, Guimarães Thais Moura, Weaver Terri E, Nery Luiz E, E Silva Luciana Oliveira, Badke Luciana, Coelho Glaury, Millani-Carneiro Aline, Tufik Sergio, Bittencourt Lia
Departamento de Medicina, Disciplina de Pneumologia, Universidade Federal de São Paulo, São Paulo, Brazil.
Departamento de Psicobiologia, Disciplina de Medicina e Biologia do Sono, Universidade Federal de São Paulo, São Paulo, Brazil.
Sleep Breath. 2016 May;20(2):681-7. doi: 10.1007/s11325-015-1279-7. Epub 2015 Nov 12.
Severe obstructive sleep apnea (OSA) directly affects the quality of life, mood, and sustained attention of individuals, but it has not yet been established in the literature, if these changes also affect patients with mild OSA. The purpose of this study was to investigate such negative effects on the parameters described above.
A controlled study was held at the Universidade Federal de Sao Paulo, Department of Psychobiology. Thirty-nine mild OSA patients and 25 controls were included. Volunteers could be of both genders with body mass index (BMI) ≤35 kg/m(2) and age between 18 and 65 years. Both groups were subjected to full-night polysomnography (PSG), the subjective assessment of mood (Beck Inventory of Anxiety and Depression), Functional Outcomes of Sleep Questionnaire (FOSQ), and the psychomotor vigilance task (PVT) five times during the day. We considered mild OSA patients those with apnea-hypopnea index (AHI) score between 5 and 15. The control group included subjects with AHI scores <5, respiratory disturbance index (RDI) scores ≤5, arousal index values ≤15, and Epworth Sleepiness Scale (ESS) values ≤9.
Mild OSA patients were older and more obese than the controls. After adjusting for age, BMI, and schooling years, there was an increased number of total lapses (3.90 ± 4.16 and 2.43 ± 5.55, p = 0.004).
Patients with mild OSA showed increased sustained attention lapses compared with normal subjects.
重度阻塞性睡眠呼吸暂停（OSA）直接影响个体的生活质量、情绪和持续注意力，但文献中尚未明确这些变化是否也会影响轻度OSA患者。本研究的目的是调查对上述参数的此类负面影响。
在圣保罗联邦大学心理生物学系进行了一项对照研究。纳入了39例轻度OSA患者和25例对照者。志愿者可为任何性别，体重指数（BMI）≤35 kg/m²，年龄在18至65岁之间。两组均接受全夜多导睡眠图（PSG）检查、情绪主观评估（贝克焦虑和抑郁量表）、睡眠功能结果问卷（FOSQ）以及白天进行5次精神运动警觉任务（PVT）。我们将呼吸暂停低通气指数（AHI）评分在5至15之间的患者视为轻度OSA患者。对照组包括AHI评分<5、呼吸紊乱指数（RDI）评分≤5、觉醒指数值≤15以及爱泼沃斯嗜睡量表（ESS）值≤9的受试者。
轻度OSA患者比对照组年龄更大且更肥胖。在调整年龄、BMI和受教育年限后，总失误次数增加（3.90±4.16和2.43±5.55，p = 0.004）。
与正常受试者相比，轻度OSA患者的持续注意力失误增加。
