结核分枝杆菌十二肽嵌合体的化学工程。
Chemical engineering of Mycobacterium tuberculosis dodecin hybrids.
机构信息
Philipps-Universität Marburg, Fachbereich Chemie, Hans-Meerwein-Strasse, 35032 Marburg, Germany.
出版信息
Chem Commun (Camb). 2011 Oct 21;47(39):11071-3. doi: 10.1039/c1cc12929e. Epub 2011 Sep 6.
PMID:21897938
Abstract
The suitability for chemical engineering of the highly symmetrical Mycobacterium tuberculosis dodecin was investigated, its inner cavity providing a large compartment shields introduced compounds from bulk solvent. Hybrids were obtained by S-alkylation of cysteine mutants and characterized by spectroscopic methods, including the crystal structures of wild type and biohybrid dodecins.
摘要
高度对称的结核分枝杆菌十二肽的化学工程适用性得到了研究，其内部腔室提供了一个大隔间，可将引入的化合物与主体溶剂隔离。通过半胱氨酸突变体的 S-烷基化获得了杂种，并通过包括野生型和生物杂种十二肽的晶体结构在内的光谱方法进行了表征。
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