Department of Chemistry, Cardiff University, Cymru/Wales, UK.
Dalton Trans. 2011 Nov 28;40(44):11663-74. doi: 10.1039/c1dt11219h. Epub 2011 Sep 6.
Transition metal lumophores are now well established as agents for cell imaging, but we are still not able to predict generally and with confidence their cellular localisation, or, for that matter, their uptake efficiencies. While many such complexes have been shown to illuminate cells, genuine applications in biomedical research will only be developed when their uptake and localisation are better understood. This perspective is not a comprehensive review of luminescence, but is an overview of attempts to control uptake and localisation, focussing on a personal account of this group's development of imaging agents based on the Re(CO)(3) bipyridine core, and our attempts to understand and control their cellular behaviour.
过渡金属荧光团现在已经被广泛应用于细胞成像，但我们仍然无法普遍且有把握地预测它们在细胞中的定位，或者，就此而言，它们的摄取效率。虽然已经有许多这样的配合物被证明可以照亮细胞，但只有当它们的摄取和定位得到更好的理解时，它们才会真正应用于生物医学研究中。本文不是对荧光的全面综述，而是对控制摄取和定位的尝试的概述，重点介绍了本课题组基于 Re(CO)(3) 联吡啶核心开发成像剂的个人经历，以及我们试图理解和控制它们的细胞行为的尝试。
