Department of Chemistry, Faculty of Science, Tshwane University of Technology (Arcadia Campus), Pretoria 0001, South Africa.
Int J Mol Sci. 2021 Jun 18;22(12):6546. doi: 10.3390/ijms22126546.
Globally, cancer is the second (to cardiovascular diseases) leading cause of death. Regardless of various efforts (i.e., finance, research, and workforce) to advance novel cancer theranostics (diagnosis and therapy), there have been few successful attempts towards ongoing clinical treatment options as a result of the complications posed by cancerous tumors. In recent years, the application of magnetic nanomedicine as theranostic devices has garnered enormous attention in cancer treatment research. Magnetic nanoparticles (MNPs) are capable of tuning the magnetic field in their environment, which positively impacts theranostic applications in nanomedicine significantly. MNPs are utilized as contrasting agents for cancer diagnosis, molecular imaging, hyperfusion region visualization, and T cell-based radiotherapy because of their interesting features of small size, high reactive surface area, target ability to cells, and functionalization capability. Radiolabelling of NPs is a powerful diagnostic approach in nuclear medicine imaging and therapy. The use of luminescent radioactive rhenium(I), Re, tricarbonyl complexes functionalised with magnetite FeO NPs in nanomedicine has improved the diagnosis and therapy of cancer tumors. This is because the combination of Re(I) with MNPs can improve low distribution and cell penetration into deeper tissues.
在全球范围内，癌症是仅次于心血管疾病的第二大死亡原因。尽管人们做出了各种努力（如资金、研究和劳动力）来推进新型癌症治疗诊断学（诊断和治疗），但由于癌症肿瘤带来的并发症，目前针对癌症的临床治疗方案仍然鲜有成功的尝试。近年来，将磁性纳米医学作为治疗诊断设备的应用在癌症治疗研究中引起了广泛关注。磁性纳米粒子（MNPs）能够调节其环境中的磁场，这对纳米医学中的治疗诊断应用产生了积极影响。MNPs 因其具有小尺寸、高反应表面积、靶向细胞的能力和功能化能力等有趣特性，被用作癌症诊断、分子成像、超融合区域可视化和基于 T 细胞的放射治疗的对比剂。纳米粒子的放射性标记是核医学成像和治疗中的一种强大诊断方法。在纳米医学中使用带有磁铁矿 FeO NPs 的发光放射性铼 (I)、Re、三羰基配合物，改善了癌症肿瘤的诊断和治疗。这是因为 Re(I)与 MNPs 的结合可以提高分布的均匀性和细胞对深层组织的穿透性。
