Center of Excellence for Nanostructured Materials (CENMAT), Department of Chemical and Pharmaceutical Sciences, and INSTM, Unit of Trieste University of Trieste, Piazzale Europa 1, 34127 Trieste, Italy.
Nanoscale. 2011 Oct 5;3(10):4035-41. doi: 10.1039/c1nr10783f. Epub 2011 Sep 7.
The fullerene family, and especially C(60), has delighted the scientific community during the last 25 years with perspective applications in a wide variety of fields, including the biological and the biomedical domains. Several biomedical uses have been explored using water-soluble C(60)-derivatives. However, the employment of fullerenes for drug delivery is still at an early stage of development. The design and synthesis of multifunctionalized and multimodal C(60) systems able to cross the cell membranes and efficiently deliver active molecules is an attracting challenge that involves multidisciplinary strategies. Promising results have emerged in the last years, bringing fullerenes again to the front of interest. Herein, the state of the art of this emerging field is presented and illustrated with some of the most representative examples.
富勒烯家族，尤其是 C(60)，在过去的 25 年里，因其在包括生物和生物医学领域在内的广泛领域的潜在应用而令科学界感到欣喜。已经探索了使用水溶性 C(60)-衍生物的几种生物医学用途。然而，富勒烯在药物输送方面的应用仍处于发展的早期阶段。设计和合成能够穿过细胞膜并有效输送活性分子的多功能化和多模态 C(60)系统是一个具有吸引力的挑战，涉及多学科策略。在过去的几年中，已经出现了有希望的结果，使富勒烯再次成为人们关注的焦点。本文介绍了这一新兴领域的最新进展，并通过一些最具代表性的例子来说明。
