Department of Chemistry, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Chem Rec. 2010 Oct;10(5):260-70. doi: 10.1002/tcr.201000021.
Long-range studies on the chemistry of two strained ring systems, cyclopropanes and fullerenes, converged on a challenge in biology, in vivo gene delivery. The new protocol of gene delivery employing a tailor-designed amino fullerene represents the third protocol after the two using virus and lipid delivery agents, none of which are universally useful. The amino fullerene delivers an EGFP and an insulin-2 gene to mice with efficiency superior to and selectivity distinct from those achieved by the conventional lipid-based delivery agents. The studies demonstrate the power of organic synthesis as driven by scientifically and socially important subjects.
对两个具有张力环体系（环丙烷和富勒烯）的化学的长期研究，汇聚到了生物学领域的一个挑战上，即体内基因传递。采用定制设计的氨基富勒烯的新基因传递方案是继使用病毒和脂质传递剂的两种方案之后的第三种方案，而这两种方案都不是普遍适用的。氨基富勒烯将 EGFP 和胰岛素-2 基因递送到小鼠体内的效率优于传统基于脂质的传递剂，并且具有独特的选择性。这些研究证明了受科学和社会重要主题驱动的有机合成的力量。
