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[一种评估糖尿病患者微量白蛋白尿的简单定性方法]

[A simple qualitative method for assessing microalbuminuria in diabetics].

作者信息

Maislos M, Budner B, Herman-Bohem I, Weitzman S

机构信息

Soroka Medical Center, Ben-Gurion, University of the Negev, Beer Sheba.

出版信息

Harefuah. 1990 Mar 15;118(6):321-2.

PMID:2189807
Abstract

Diabetes mellitus is one of the most important causes of kidney diseases, the first sign of which is albuminuria. It is now possible to detect microalbuminuria before the appearance of larger quantities. We compared a simple qualitative test for microalbuminuria (change in color of a tablet containing bromphenol blue on addition of urine) with a more elaborate quantitative immunoturbidometric method. Of 109 samples tested 31 were positive by the quantitative method and 29 of these were positive by the tablet method. Out of the 78 negative by the quantitative method only 4 were positive by the qualitative test. The sensitivity of the tablet test was 93.5%, specificity 94.0%, positive predictive value 87.9%, negative predictive value 97.4%, false positive rate 5.2%, and false negative rate 6.2%. We conclude that the tablet test is simple and accurate and is suitable both for screening of large populations and for the diagnosis of individual cases of microalbuminuria.

摘要

糖尿病是导致肾脏疾病的最重要原因之一,其首个迹象是蛋白尿。现在能够在出现大量蛋白尿之前检测出微量白蛋白尿。我们将一种用于检测微量白蛋白尿的简单定性试验(在加入尿液后含溴酚蓝的片剂颜色变化)与一种更精细的定量免疫比浊法进行了比较。在检测的109份样本中,定量法检测出31份呈阳性,其中29份通过片剂法检测也呈阳性。在定量法检测为阴性的78份样本中,只有4份通过定性试验呈阳性。片剂试验的灵敏度为93.5%,特异性为94.0%,阳性预测值为87.9%,阴性预测值为97.4%,假阳性率为5.2%,假阴性率为6.2%。我们得出结论,片剂试验简单且准确,既适用于大规模人群筛查,也适用于微量白蛋白尿个体病例的诊断。

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