Department of Histology and Embryology, Faculty of Medicine, University of Rijeka, B. Branchetta 20, 51000 Rijeka, Croatia.
Cell Mol Life Sci. 2011 Nov;68(21):3519-29. doi: 10.1007/s00018-011-0797-0. Epub 2011 Sep 6.
NKG2D is one of the most intensively studied immune receptors of the past decade. Its unique binding and signaling properties, expression pattern, and functions have been attracting much interest within the field due to its potent antiviral and anti-tumor properties. As an activating receptor, NKG2D is expressed on cells of the innate and adaptive immune system. It recognizes stress-induced MHC class I-like ligands and acts as a molecular sensor for cells jeopardized by viral infections or DNA damage. Although the activating functions of NKG2D have been well documented, recent analysis of NKG2D-deficient mice suggests that this receptor may have a regulatory role during NK cell development. In this review, we will revisit known aspects of NKG2D functions and present new insights in the proposed influence of this molecule on hematopoietic differentiation.
NKG2D 是过去十年中研究最为深入的免疫受体之一。由于其强大的抗病毒和抗肿瘤特性，其独特的结合和信号转导特性、表达模式和功能在该领域引起了广泛关注。作为一种激活受体，NKG2D 表达于先天和适应性免疫系统的细胞上。它识别应激诱导的 MHC 类 I 样配体，并作为受到病毒感染或 DNA 损伤威胁的细胞的分子传感器。尽管 NKG2D 的激活功能已得到充分证实，但对 NKG2D 缺陷小鼠的最新分析表明，该受体在 NK 细胞发育过程中可能具有调节作用。在这篇综述中，我们将重新审视 NKG2D 功能的已知方面，并提出该分子对造血分化影响的新见解。
