Grando S A, Drannik G N, Glukhenky B T, Kostromin A P, Romanenko A B, Chayun O A, Chernyavski A I
Unit of Immunodermatology & Extracorporeal Detoxification, UkrSSR Academy of Sciences.
Int J Artif Organs. 1990 Mar;13(3):181-8.
Hemocarboadsorption (HCA) with the following immunosuppressive therapy was used to treat 48 patients with pemphigus vulgaris (PV) and 31 patients with bullous pemphigoid (BP) in the acute phase. The levels of autoantibodies, eicosanoids, endoproteases and their inhibitors as well as interleukin (IL) 1 and IL 2 production and absorption of exogenous IL 2 were examined in the treatment dynamics. The therapeutic effect of HCA was displayed in prompt disease remission in 43 PV and 29 BP patients. Clinical improvement was accompanied by antibody elimination and interleukin cascade reaction normalization. HCA resulted in growth of patients' serum immunosuppressive activity. It was concluded that HCA has some immunoregulatory effect (Int J Artif Organs; 1990: 13: 181-88).
采用血液碳吸附（HCA）联合以下免疫抑制疗法，对48例急性期寻常型天疱疮（PV）患者和31例大疱性类天疱疮（BP）患者进行治疗。在治疗过程中，检测了自身抗体、类花生酸、内切蛋白酶及其抑制剂水平，以及白细胞介素（IL）-1和IL-2的产生情况和外源性IL-2的吸收情况。HCA的治疗效果表现为43例PV患者和29例BP患者病情迅速缓解。临床症状改善的同时，抗体消除，白细胞介素级联反应恢复正常。HCA使患者血清免疫抑制活性增强。得出结论：HCA具有一定的免疫调节作用（《国际人工器官杂志》；1990年；第13卷：第181 - 188页）。
