Identification and characterization of inhibitors of the aminoglycoside resistance acetyltransferase Eis from Mycobacterium tuberculosis.
作者信息
Green Keith D, Chen Wenjing, Garneau-Tsodikova Sylvie
机构信息
Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.
出版信息
ChemMedChem. 2012 Jan 2;7(1):73-7. doi: 10.1002/cmdc.201100332. Epub 2011 Sep 5.
Abstract
摘要
相似文献
1
Identification and characterization of inhibitors of the aminoglycoside resistance acetyltransferase Eis from Mycobacterium tuberculosis.结核分枝杆菌氨基糖苷类耐药乙酰转移酶Eis抑制剂的鉴定与表征
ChemMedChem. 2012 Jan 2;7(1):73-7. doi: 10.1002/cmdc.201100332. Epub 2011 Sep 5.
2
Probing the Robustness of Inhibitors of Tuberculosis Aminoglycoside Resistance Enzyme Eis by Mutagenesis.通过诱变探究结核氨基糖苷类耐药酶Eis抑制剂的稳健性
ACS Infect Dis. 2019 Oct 11;5(10):1772-1778. doi: 10.1021/acsinfecdis.9b00228. Epub 2019 Aug 21.
3
Potent 1,2,4-Triazino[5,6 b]indole-3-thioether Inhibitors of the Kanamycin Resistance Enzyme Eis from Mycobacterium tuberculosis.结核分枝杆菌卡那霉素抗性酶Eis的强效1,2,4-三嗪并[5,6 -b]吲哚-3-硫醚抑制剂
ACS Infect Dis. 2018 Jun 8;4(6):1030-1040. doi: 10.1021/acsinfecdis.8b00074. Epub 2018 Mar 30.
4
Structure-Guided Optimization of Inhibitors of Acetyltransferase Eis from .基于结构的.乙酰转移酶 Eis 抑制剂的优化
ACS Chem Biol. 2020 Jun 19;15(6):1581-1594. doi: 10.1021/acschembio.0c00184. Epub 2020 May 18.
5
Potent Inhibitors of Acetyltransferase Eis Overcome Kanamycin Resistance in Mycobacterium tuberculosis.乙酰转移酶Eis的强效抑制剂克服了结核分枝杆菌对卡那霉素的耐药性。
ACS Chem Biol. 2016 Jun 17;11(6):1639-46. doi: 10.1021/acschembio.6b00110. Epub 2016 Apr 7.
6
Combating Enhanced Intracellular Survival (Eis)-Mediated Kanamycin Resistance of Mycobacterium tuberculosis by Novel Pyrrolo[1,5-a]pyrazine-Based Eis Inhibitors.新型基于吡咯并[1,5-a]吡嗪的Eis抑制剂对抗结核分枝杆菌增强的细胞内存活（Eis）介导的卡那霉素耐药性
ACS Infect Dis. 2017 Apr 14;3(4):302-309. doi: 10.1021/acsinfecdis.6b00193. Epub 2017 Feb 17.
7
Redesign of substrate specificity and identification of the aminoglycoside binding residues of Eis from Mycobacterium tuberculosis.结核分枝杆菌 Eis 蛋白的底物特异性改造及结合残基鉴定。
Biochemistry. 2013 Jul 30;52(30):5125-32. doi: 10.1021/bi4002985. Epub 2013 Jul 16.
8
Unusual regioversatility of acetyltransferase Eis, a cause of drug resistance in XDR-TB.乙酰转移酶 Eis 的不寻常区域变构作用，导致 XDR-TB 产生耐药性。
Proc Natl Acad Sci U S A. 2011 Jun 14;108(24):9804-8. doi: 10.1073/pnas.1105379108. Epub 2011 May 31.
9
A consensus reverse docking approach for identification of a competitive inhibitor of acetyltransferase enhanced intracellular survival protein from Mycobacterium tuberculosis.一种共识反向对接方法，用于鉴定结核分枝杆菌乙酰转移酶增强细胞内存活蛋白的竞争性抑制剂。
Bioorg Med Chem. 2024 Jun 15;108:117774. doi: 10.1016/j.bmc.2024.117774. Epub 2024 May 26.
10
Biochemical and structural analysis of aminoglycoside acetyltransferase Eis from Anabaena variabilis.可变鱼腥藻氨基糖苷乙酰转移酶Eis的生化与结构分析
Mol Biosyst. 2012 Oct 30;8(12):3305-13. doi: 10.1039/c2mb25341k.
引用本文的文献
1
Suppressing Mycobacterium tuberculosis virulence and drug resistance by targeting Eis protein through computational drug discovery.通过计算机辅助药物发现靶向Eis蛋白抑制结核分枝杆菌的毒力和耐药性
Mol Divers. 2025 Apr;29(2):1697-1723. doi: 10.1007/s11030-024-10946-1. Epub 2024 Aug 3.
2
Targeting Aminoglycoside Acetyltransferase Activity of Mycobacterium tuberculosis (H37Rv) Derived Eis (Enhanced Intracellular Survival) Protein with Quercetin.利用槲皮素靶向结核分枝杆菌（H37Rv）衍生的 Eis（增强细胞内存活）蛋白的氨基糖苷乙酰转移酶活性。
Protein J. 2024 Feb;43(1):12-23. doi: 10.1007/s10930-023-10165-x. Epub 2023 Nov 6.
3
Discovery and development of inhibitors of acetyltransferase Eis to combat Mycobacterium tuberculosis.发现和开发乙酰转移酶 Eis 的抑制剂以对抗结核分枝杆菌。
Methods Enzymol. 2023;690:369-396. doi: 10.1016/bs.mie.2023.06.017. Epub 2023 Jul 27.
4
Discovery and Mechanistic Analysis of Structurally Diverse Inhibitors of Acetyltransferase Eis among FDA-Approved Drugs.发现并分析 FDA 批准药物中具有结构多样性的乙酰转移酶 Eis 抑制剂。
Biochemistry. 2023 Feb 7;62(3):710-721. doi: 10.1021/acs.biochem.2c00658. Epub 2023 Jan 19.
5
Discovery of substituted benzyloxy-benzylamine inhibitors of acetyltransferase Eis and their anti-mycobacterial activity.取代的苯甲氧基-苄基胺乙酰转移酶 Eis 抑制剂的发现及其抗分枝杆菌活性。
Eur J Med Chem. 2022 Nov 15;242:114698. doi: 10.1016/j.ejmech.2022.114698. Epub 2022 Aug 18.
6
Structure-based design of haloperidol analogues as inhibitors of acetyltransferase Eis from to overcome kanamycin resistance.基于结构设计氟哌啶醇类似物作为来自[具体来源]的乙酰转移酶Eis抑制剂以克服卡那霉素抗性。
RSC Med Chem. 2021 Oct 5;12(11):1894-1909. doi: 10.1039/d1md00239b. eCollection 2021 Nov 17.
7
Retention of antibiotic activity against resistant bacteria harbouring aminoglycoside-N-acetyltransferase enzyme by adjuvants: a combination of in-silico and in-vitro study.通过佐剂保留对携带氨基糖苷-N-乙酰转移酶酶的耐药菌的抗生素活性：一项计算机模拟和体外研究的结合。
Sci Rep. 2020 Nov 9;10(1):19381. doi: 10.1038/s41598-020-76355-0.
8
Structure-Guided Optimization of Inhibitors of Acetyltransferase Eis from .基于结构的.乙酰转移酶 Eis 抑制剂的优化
ACS Chem Biol. 2020 Jun 19;15(6):1581-1594. doi: 10.1021/acschembio.0c00184. Epub 2020 May 18.
9
Multitarget Approaches against Multiresistant Superbugs.针对多重耐药超级细菌的多靶点方法。
ACS Infect Dis. 2020 Jun 12;6(6):1346-1365. doi: 10.1021/acsinfecdis.0c00001. Epub 2020 Mar 19.
10
Comprehensive analysis of protein acetyltransferases of human pathogen Mycobacterium tuberculosis.全面分析人类病原体结核分枝杆菌的蛋白质乙酰转移酶。
Biosci Rep. 2019 Dec 20;39(12). doi: 10.1042/BSR20191661.
本文引用的文献
1
Unusual regioversatility of acetyltransferase Eis, a cause of drug resistance in XDR-TB.乙酰转移酶 Eis 的不寻常区域变构作用，导致 XDR-TB 产生耐药性。
Proc Natl Acad Sci U S A. 2011 Jun 14;108(24):9804-8. doi: 10.1073/pnas.1105379108. Epub 2011 May 31.
2
Effects of altering aminoglycoside structures on bacterial resistance enzyme activities.改变氨基糖苷类结构对细菌耐药酶活性的影响。
Antimicrob Agents Chemother. 2011 Jul;55(7):3207-13. doi: 10.1128/AAC.00312-11. Epub 2011 May 2.
3
Combinations of antibiotics and nonantibiotic drugs enhance antimicrobial efficacy.抗生素与非抗生素药物联合使用可提高抗菌疗效。
Nat Chem Biol. 2011 Jun;7(6):348-50. doi: 10.1038/nchembio.559. Epub 2011 Apr 24.
4
Assessment of 6'- and 6'''-N-acylation of aminoglycosides as a strategy to overcome bacterial resistance.评估 6'- 和 6'''-N-酰化氨基糖苷类抗生素作为克服细菌耐药性的策略。
Org Biomol Chem. 2011 Jun 7;9(11):4057-63. doi: 10.1039/c0ob01133a. Epub 2011 Mar 1.
5
Acute pulmonary toxic effects of chlorhexidine (CHX) following an intratracheal instillation in rats.大鼠气管内滴注洗必泰（CHX）后的急性肺毒性作用。
Hum Exp Toxicol. 2011 Nov;30(11):1795-803. doi: 10.1177/0960327111400104. Epub 2011 Feb 21.
6
Molecular detection of mutations associated with first- and second-line drug resistance compared with conventional drug susceptibility testing of Mycobacterium tuberculosis.与传统结核分枝杆菌药物敏感性试验相比，检测与一线和二线耐药相关的基因突变。
Antimicrob Agents Chemother. 2011 May;55(5):2032-41. doi: 10.1128/AAC.01550-10. Epub 2011 Feb 7.
7
The challenge of new drug discovery for tuberculosis.结核病新药研发面临的挑战。
Nature. 2011 Jan 27;469(7331):483-90. doi: 10.1038/nature09657.
8
Mycobacterium tuberculosis eis regulates autophagy, inflammation, and cell death through redox-dependent signaling.结核分枝杆菌 Eis 通过依赖氧化还原的信号转导调节自噬、炎症和细胞死亡。
PLoS Pathog. 2010 Dec 16;6(12):e1001230. doi: 10.1371/journal.ppat.1001230.
9
Treatment of tuberculosis: update 2010.结核病治疗：2010 年更新。
Eur Respir J. 2011 Feb;37(2):441-62. doi: 10.1183/09031936.00033010. Epub 2010 Sep 16.
10
Aminoglycoside modifying enzymes.氨基糖苷修饰酶。
Drug Resist Updat. 2010 Dec;13(6):151-71. doi: 10.1016/j.drup.2010.08.003. Epub 2010 Sep 15.
Zotero 插件