Maino D M, Schlange D, Maino J H, Caden B
Illinois College of Optometry, Chicago 60616.
J Am Optom Assoc. 1990 Apr;61(4):316-23.
Fragile X (fra[X]) syndrome is a newly discovered, but relatively common, genetic disorder with an estimated frequency of 1:1000. Several ocular dysfunctions may be associated with this syndrome, but there are few articles that fully report on these. A review of this genetic disorder is provided, as well as a discussion of a case review of a family with three siblings with fragile X syndrome. Since this disorder is the most common familial cause of mental retardation, is second only to Down's syndrome as a genetic cause for mental retardation, and may play a significant role in learning disabilities, the eye care practitioner should be aware of its importance.
脆性X综合征（fra[X]）是一种新发现但相对常见的遗传性疾病，估计发病率为1:1000。该综合征可能与多种眼部功能障碍有关，但全面报道这些情况的文章较少。本文对这种遗传性疾病进行了综述，并对一个有三名患有脆性X综合征的兄弟姐妹的家庭案例进行了讨论。由于这种疾病是智力发育迟缓最常见的家族性病因，作为智力发育迟缓的遗传病因仅次于唐氏综合征，并且可能在学习障碍中起重要作用，眼科医生应意识到其重要性。
