Plezia P M, Alberts D S, Kessler J F, Berens P L, Chase J L, Roe D J
J Pain Symptom Manage. 1990 Apr;5(2):101-8. doi: 10.1016/s0885-3924(05)80023-5.
In a randomized open crossover study, the antiemetic efficacy of a five-drug antiemetic regimen consisting of metoclopramide, dexamethasone, diazepam, diphenhydramine, and thiethylperazine was compared to that of high-dose metoclopramide. Thirteen patients treated with cisplatin combination chemotherapy regimens were evaluated. The study was terminated prior to accrual of the planned number of patients because of the statistically significant difference in efficacy between treatments found at interim analysis. The duration of nausea and number of vomiting episodes on the day of chemotherapy were significantly less (p less than 0.01) after receiving the five-drug combination. After receiving the five-drug regimen, 77% of the patients did not experience any episodes of vomiting on day 1, and 8% of patients had only one episode. In contrast, only 31% of patients treated with high-dose metoclopramide did not have any episodes of vomiting on day 1, and 61% of the patients had five or more episodes. None of the patients treated with the five-drug regimen required additional antiemetic administration. Although both regimens were, in general, well tolerated, when given the choice of continuing antiemetic therapies, 92% of the patients preferred the five-drug antiemetic combination.
在一项随机开放交叉研究中，将由胃复安、地塞米松、地西泮、苯海拉明和硫乙拉嗪组成的五药联合止吐方案的止吐效果与高剂量胃复安的止吐效果进行了比较。对13例接受顺铂联合化疗方案治疗的患者进行了评估。由于中期分析发现治疗之间的疗效存在统计学显著差异，该研究在纳入计划数量的患者之前就终止了。接受五药联合治疗后，化疗当天恶心的持续时间和呕吐发作次数显著减少（p<0.01）。接受五药方案后，77%的患者在第1天没有经历任何呕吐发作，8%的患者只有一次发作。相比之下，接受高剂量胃复安治疗的患者中，只有31%在第1天没有任何呕吐发作，61%的患者有5次或更多次发作。接受五药方案治疗的患者均无需额外给予止吐药。虽然两种方案总体上耐受性良好，但在选择继续使用止吐疗法时，92%的患者更喜欢五药联合止吐方案。
