杂芳基卤化物和芳基硼酸的铃木-宫浦交叉偶联反应在连续流中进行。
Suzuki-Miyaura cross-coupling of heteroaryl halides and arylboronic acids in continuous flow.
机构信息
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
出版信息
Org Lett. 2011 Oct 7;13(19):5180-3. doi: 10.1021/ol202052q. Epub 2011 Sep 7.
PMID:21899298
Abstract
General continuous-flow conditions for the Suzuki-Miyaura cross-coupling of heteroaryl halides and (hetero)arylboronic acids have been developed. A wide range of heterobiaryl products is obtained in excellent yields (20 examples) employing low catalyst loadings (0.05-1.5 mol % Pd).
摘要
已经开发出了杂芳基卤化物和（杂）芳基硼酸的 Suzuki-Miyaura 交叉偶联的一般连续流动条件。采用低催化剂负载量（0.05-1.5 mol % Pd），可获得广泛的杂联芳基产物，产率优异（20 个实例）。
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