Furfaro Nicole, Mease Philip J
Seattle Rheumatology Associates, Seattle, Washington 98104, USA.
J Am Acad Nurse Pract. 2011 Sep;23(9):479-92. doi: 10.1111/j.1745-7599.2011.00665.x.
To provide a general overview of clinical trials and more specifically define measurements common to rheumatoid arthritis clinical trials for the purpose of providing a foundation for rheumatology healthcare providers to translate clinical trial findings into their clinical practice and enhance their patient education discussions.
English-language publications cited in the MEDLINE database were used to develop the content of this review article.
The role of rheumatology healthcare providers has evolved to include numerous vital functions, such as expanding communication between specialists and primary care providers, patient education and counseling, assistance with coping strategies, monitoring response to therapy, and administration of therapy. Education regarding clinical trial design, rationale, and discussion of endpoints has not been strongly emphasized for rheumatology healthcare providers who are increasingly introduced to novel agents and need to assimilate findings from clinical trials into daily practice.
Familiarity with the basics of clinical trial design and efficacy endpoints of new rheumatoid arthritis therapeutics, translation and application of that knowledge into daily practice, and the ability to explain this information with patients will further enhance the ability of the rheumatology healthcare provider to optimize care for their patients with rheumatoid arthritis.
提供临床试验的总体概述，并更具体地定义类风湿关节炎临床试验中常用的测量方法，以便为风湿病医疗服务提供者将临床试验结果转化为临床实践并加强患者教育讨论奠定基础。
本综述文章的内容基于MEDLINE数据库中引用的英文出版物。
风湿病医疗服务提供者的角色已经演变，包括许多重要职能，如扩大专科医生与初级保健提供者之间的沟通、患者教育与咨询、协助应对策略、监测治疗反应以及实施治疗。对于越来越多地接触新药物且需要将临床试验结果融入日常实践的风湿病医疗服务提供者，关于临床试验设计、原理和终点讨论的教育并未得到充分强调。
熟悉新的类风湿关节炎治疗方法的临床试验设计基础和疗效终点，将这些知识转化并应用于日常实践，以及向患者解释这些信息的能力，将进一步提高风湿病医疗服务提供者为类风湿关节炎患者优化治疗的能力。
