Rudman D, Kutner M H, Goldsmith M A, Blackston R D
J Clin Endocrinol Metab. 1979 Mar;48(3):472-7. doi: 10.1210/jcem-48-3-472.
A previous study showed that when GH-deficient children below the third percentile in height are treated with 0.168 U human GH (hGH)/kg BW3/4 for 10 days, their height increases by 0.3--1.9 cm during the next 8 weeks. The present study determined whether this acute response would predict the child's long term response to 1 yr of treatment with the same dose of hGH given three times a week. Eighteen GH-deficient children and adolescents, aged 8--16 yr, were measured every 2 weeks over 108 weeks. After a control period of 12 weeks (period 1), the patient received hGH for 10 days. During the remainder of the 12 weeks of period 2 and during the next 12 weeks (period 3), hGH was not given. Patients recieved hGH three times a week during periods 4 and 5 (24 weeks each). Periods 6 and 7 (12 weeks each) were posttreatment control periods. During periods 1, 3, 6, and 7, rate of growth was less than 0.2 cm/month. During period 2, the rate ranged between 0.1--0.8 cm/month. During periods 4 and 5, the growth rate ranged from 0.2--1.0 cm/month. Rate of growth during periods 4 and 5 (y) was related to rate during period 2 (x) by the equation y = 0.027 + 1.17 x. The correlation coefficient between y and x was 0.91 (P less than 0.001). The increment in height which will occur during 48 weeks of treatment can be predicted from the response to 10 days of treatment by this equation. The SE of the prediction averages +/- 1.2 cm/yr.
先前的一项研究表明，对于身高处于第三百分位数以下的生长激素缺乏儿童，给予0.168 U人重组生长激素（hGH）/kg体重3/4，持续治疗10天，在接下来的8周内他们的身高增长0.3 - 1.9厘米。本研究旨在确定这种急性反应是否能预测儿童对每周三次给予相同剂量hGH进行1年治疗的长期反应。18名年龄在8 - 16岁的生长激素缺乏儿童和青少年，在108周内每2周测量一次。在12周的对照期（第1阶段）后，患者接受hGH治疗10天。在第2阶段的剩余12周以及接下来的12周（第3阶段），未给予hGH。在第4和第5阶段（各24周）患者每周接受三次hGH治疗。第6和第7阶段（各12周）为治疗后对照期。在第1、3、6和7阶段，生长速率小于0.2厘米/月。在第2阶段，生长速率在0.1 - 0.8厘米/月之间。在第4和第5阶段，生长速率在0.2 - 1.0厘米/月之间。第4和第5阶段的生长速率（y）与第2阶段的生长速率（x）通过方程y = 0.027 + 1.17x相关。y与x之间的相关系数为0.91（P < 0.001）。通过该方程可根据10天治疗的反应预测48周治疗期间身高的增加量。预测的标准误平均为±1.2厘米/年。
