Academic Section of Vascular Surgery, Department of Surgery & Cancer, Imperial College, London, UK.
Angiology. 2012 Jul;63(5):367-77. doi: 10.1177/0003319711418958. Epub 2011 Sep 7.
Differences between animal and human atherosclerosis have led to the requirement for clinical data, imaging information and biological material from large numbers of patients and healthy persons. Where such "biobanks" exist, they have been fruitful sources for genomewide association, diagnostic accuracy, ethnicity, and risk stratification cohort studies. In addition once established, they attract funding for future projects. Biobanks require a network of medical contributors, secure storage facilities, bioinformatics expertise, database managers, and ethical working practices to function optimally. There is the opportunity for collaboration between individual biobanks to further amplify the advantages afforded.
动物和人类动脉粥样硬化之间的差异导致需要大量患者和健康人群的临床数据、影像信息和生物材料。在存在这种“生物库”的地方，它们为全基因组关联、诊断准确性、种族和风险分层队列研究提供了丰富的来源。此外，一旦建立，它们就会吸引未来项目的资金。生物库需要一个由医疗贡献者、安全存储设施、生物信息学专业知识、数据库管理人员和道德工作实践组成的网络，以实现最佳运作。各个生物库之间有合作的机会，可以进一步放大所提供的优势。
